Studies suggest that, rather than acting primarily through GLP-1-producing neurons in the hindbrain or GLP-1 receptors in the vagus nerve, these drugs mediate weight loss via the arcuate nucleus (ARC) of the hypothalamus [55,56]
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doi: 10.1038/nature25979 39 LeeHLeeYKimJAnJLeeSKongHet al
Tirzepatide is actively studied in research on dual incretin receptor pharmacology, adipose tissue biology, beta-cell preservation, NASH resolution, obstructive sleep apnea, heart failure with preserved ejection fraction (HFpEF), and polycystic kidney disease
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus